The nature of fibrous dysplasia

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The nature of fibrous dysplasia

Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsalpha subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentia...

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Craniofacial Fibrous Dysplasia

Fibrous dysplasia (FD) is an osseous growth dis-order, producing immature bone and characte-rized by the replacement of normal bone with fibro-osseous connective tissue. It is a bone dys-plasia that has the potential to cause significant cosmetic and functional disturbances, particularly in the craniofacial skeleton. Cra-niofacial fibrous dysplasia is one of the three types of polyostotic fibro...

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Craniofacial Fibrous Dysplasia of Zygomaticomaxillary Complex

Fibrous dysplasia is a benign bone disease first described by Lichtenstein in 1938. It is characterized by progressive replacement of normal bone with fibro-osseous connective tissue. When the disease involves craniofacial skeleton, it results in significant disfigurement and other functional problems. This paper reports a case of large craniofacial fibrous dysplasia involving zygomaticomaxilla...

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Fibrous dysplasia of the orbit.

Twelve patients with fibrous dysplasia of the orbit are reviewed and the ophthalmic findings described. Three case histories are presented in detail. Six patients were managed conservatively; four have shown radiological progression of the disease. Six patients underwent surgery. A conservative procedure, comprising debulking dysplastic bone, was carried out in four--all required further surger...

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Craniofacial fibrous dysplasia: New image findings

Introdouction: Fibrous dysplasia is a benign fibro-osseous lesion that affects craniofacial bones including the maxilla and mandible. In the most cases of fibrous dysplasia of facial bones, radiographic findings represent lucent or mixed radiolucent-radiopaque lesion with ill-defined borders and gradual blending of its border with adjacent bone . In this presentation, a patient suffering ...

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ژورنال

عنوان ژورنال: Head & Face Medicine

سال: 2009

ISSN: 1746-160X

DOI: 10.1186/1746-160x-5-22